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BCRJ: 0269
Cell Line: PC-3
Tissue:
Organ: PROSTATA
Cell Type: B LYMPHOCYTE
Morphology: EPITHELIAL
Pathology: ADENOCARCINOMA
Scientific Name: HOMO SAPIENS
Vulgar Name: HUMAN
Sex: MALE
Miscelaneous Info: 62 YEARS
Virus Succeptibility:
Virus Resistance:
Tumor Formation: YES
Products:
Dependency Isoenzymes:
Culture Medium: The base medium for this cell line is F-12K Medium 10% of fetal bovine serum..
Consigner: HERNANDES FAUSTINO DE CARVALHO UNIVERSIDADE ESTADUAL DE CAMPINAS LABORATORIO DE MATRIZ EXTRACELULAR
Reference: 22363: Kaighn ME, et al. Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest. Urol. 17: 16-23, 1979. PubMed: 447482 22470: Chen TR. Chromosome identity of human prostate cancer cell lines, PC-3 and PPC-1. Cytogenet. Cell Genet. 62: 183-184, 1993. PubMed: 8428522 26302: Ohnuki Y, et al. Chromosomal analysis of human prostatic adenocarcinoma cell lines. Cancer Res. 40: 524-534, 1980. PubMed: 7471073 32341: Sheng S, et al. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells. Proc. Natl. Acad. Sci. USA 93: 11669-11674, 1996. PubMed: 8876194 32344: Umekita Y, et al. Human prostate tumor growth in athymic mice: inhibition by androgens and stimulation by finasteride. Proc. Natl. Acad. Sci. USA 93: 11802-11807, 1996. PubMed: 8876218 32460: Carter RE, et al. Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. Proc. Natl. Acad. Sci. USA 93: 749-753, 1996. PubMed: 8570628 32486: Nupponen NN, et al. Genetic alterations in prostate cancer cell lines detected by comparative genomic hybridization. Cancer Genet. Cytogenet. 101: 53-57, 1998. PubMed: 9460501 32488: Geiger T, et al. Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice. Anticancer Drug Des. 13: 35-45, 1998. PubMed: 9474241 32916: Su ZZ, et al. Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. Proc. Natl. Acad. Sci. USA 93: 7252-7257, 1996. PubMed: 8692978.
Additional Info: The cells form clusters in soft agar and can be adapted to suspension growth; Antigen Expression: HLA A1, A9;
ATCC: CRL-1435
Biosafety: 1


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