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BCRJ:	0243
Cell Line:	UMR-106
Tissue:
Organ:	BONE
Cell Type:	EPITHELIAL
Morphology:	EPITHELIAL
Pathology:	OSTEOSARCOMA
Scientific Name:	RATTUS NORVEGICUS
Vulgar Name:	RAT
Sex:
Miscelaneous Info:
Virus Succeptibility:
Virus Resistance:
Tumor Formation:
Products:
Dependency Isoenzymes:
Culture Medium:	Dulbecco’s MEM 90%, fetal bovine serum 10%. Propagation procedure: standard tripsinization techniques. A split ratio 1:3 to 1:6 is recommended.
Consigner:	Dr. Willian George Goodman, Deparment of Radiololgy, UCLA School of Medicine through Dr. Maria Eugênia Leite Duarte, Departamento de Patologia, HUAP, UFF, Niterói.
Reference:	Nature (Lond. ) 260: 436-438, 1976; Eur. J. Cancer 15: 1151-1158, 1979; Clin. Orthop. Rel. Res. 140: 247-254, 1979; FEBS Lett. 115: 139-142,1980; Cancer Res. 43: 4308-4315, 1983; Methods Enzymol. 145: 324-336; 1987;
Additional Info:	This cell line is a cloned derivative of a transplantable rat osteogenic sarcoma. The parental tumor was induced in a Sprague Dawley rat by intraperitoneal injection of 32P. The cells retain many of the characteristics of the tumor including responsiveness to parathyroid hormone ( PTH ), cytosol receptors for the bone resorbing steroid hormone 1,25-OH2D3 and the responsiveness to prostaglandins. The origin of this cell line should be acknowledged in all relevent publications. May be distributed to scientific institutions; not to distributed for any commercial use.
ATCC:	CRL1661
Biosafety:	01