| BCRJ: | 0176 |
| Cell Line: | MOLT-4 |
| Tissue: | HEMATOPOIETIC |
| Organ: | PERIPHERAL BLOOD |
| Cell Type: | LYMPHOBLAST |
| Morphology: | LYMPHOBLAST |
| Pathology: | LEUKEMIA |
| Scientific Name: | HOMO SAPIENS |
| Vulgar Name: | HUMAN |
| Sex: | |
| Miscelaneous Info: | |
| Virus Succeptibility: | |
| Virus Resistance: | |
| Tumor Formation: | |
| Products: | |
| Dependency Isoenzymes: | |
| Culture Medium: | RPMI 1640 medium with 10% fetal calf serum. Fluid renewal three times a week.
Split ratio 1:3 to 1:6 recommended. |
| Consigner: | Dr. Eliana Saul Abdelhay
Lab. Biologia Molecular Maury Miranda
Instituto de Biofísica Carlos Chagas Fo
CCS/UFRJ |
| Reference: | J. Natl. Canscer Inst., 49: 891-895, 1972 |
| Additional Info: | MOLT-4 is a suspension culture derived from peripheral blood of a 19-year-old
male with acute lymphoblastic leukemia in relapse. It is reportedly a stable T- cell
leukemia; the cells bind to sheep erytrocytes to form rosettes. High leves of terminal deoxynucleotidyl transferase (TdT) activity is high.
Ig and EBV not detected. Hypertetraploid cell line, with reported 6q- and t(7;7). Also
i(17q) reported to some cells. Mutation at codon 248 of the gene p53 (G-->A). p53 is not expressed. May be distributed for research purposes. Not for commercial use |
| ATCC: | CRL-1582 |
| Biosafety: | 01 |
